孙斌 医学博士
副教授 博士生导师
济南市文化西路44号，山东大学药学院新科研楼302室
联系电话：0531-88382235
联系邮箱：sunbin@sdu.edu.cn
学习和工作经历
2001.09-2005.07，山东大学，药学院药学专业，理学学士；
2005.09-2010.07，山东大学，药学院药物化学专业，医学博士（导师：娄红祥教授）；
2008.09-2009.09，普渡大学，药学院药物化学专业，联合培养博士研究生。
2010.07-至今，山东大学国家糖工程技术研究中心，讲师，副教授；
2018年获山东大学“青年学者未来计划”人才计划支持。
研究方向
1.抗肿瘤和抗真菌活性天然产物的合成、衍生物制备和作用机制研究；
2.一氧化氮供体型化合物的设计、合成和抗肿瘤活性研究；
3.抗凝血创新药物的研究与开发。
主持项目
1.国家自然科学基金，苯醌还原酶2抑制剂的设计、合成及其化学预防作用机制研究（811021319）
2.山东省自然科学基金，基于苯醌还原酶2晶体结构的白藜芦醇类似物的设计、合成和活性研究（ZR2011HQ024）
3.山东省重点研发计划重大新药创制子课题，小分子PAR-1抑制剂1.1类抗凝血新药舒心帕沙的临床前研究（2017CXGC1403）
4.中国博士后第49批面上项目，苯醌还原酶2抑制剂的设计、合成及其化学预防作用机制研究（20110491602）
5.山东省重点研发计划公益类项目，靶向溶酶体的双联苄衍生物的合成、抗肿瘤活性研究和成药性研究（GG201709190112）
6.山东大学青年学者未来计划项目，肿瘤靶向性一氧化氮供体型化合物的制备及抗肿瘤作用机制研究（2018WLJH41）
代表论文
1. Xiaoyu Zhao#,Bin Sun#, Hongbo Zheng, Jun Liu, Xiaoning Wang*, Hongxiang Lou*, Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors,Bioorganic & Medicinal Chemistry Letters,2018, 28: 2201-2205.
2. Changyi Cui, Jun Liu, Hongbo Zheng, Xueyang Jin, Xiaoyu Zhao, Wenqiang Chang,Bin Sun*, Hongxiang Lou*, Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance inCandida albicans,Bioorganic & Medicinal Chemistry Letters,2018, 28: 1545-1549.
3. Jun Liu#,Bin Sun#, Xiaoyu Zhao, Jie Xing, Yanhui Gao, Wenqiang Chang, Jianbo Ji, Hongbo Zheng, Changyi Cui, Aiguo Ji*, Hongxiang Lou*, Discovery of potent orally active protase-activated receptor 1 (PAR1) antagonist based on andrographolide,Journal of Medicinal Chemistry,2017, 60 (16): 7166-7185
4.Bin Sun#, Jun Liu#, Yun Gao, Hongbo Zheng, Lin Li, Qingwen Hu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome,European Journal of Medicinal Chemistry,2017, 136:603-618
5.Bin Sun, Lin Li, Qingwen Hu, Hongbo Zheng, Hui Tang, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents,European Journal of Medicinal Chemistry,2017, 129:186-208
6.Bin Sun, Ming Zhang, Ying Li, Qingwen Hu, Hongbo Zheng, Wenqiang Chang, Hongxiang Lou*, Synthesis of riccardin D derivatives as potent antimicrobial agents,Bioorganic & Medicinal Chemistry Letters,2016, 26 (15): 3617-3620
7.Bin Sun, Lin Li, Qingwen Hu, Fei Xie, Hongbo Zheng, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors,European Journal of Medicinal Chemistry,2016, 121: 484-499
8. Xigong Liu#,Bin Sun#, Zhiyu Xie, Xiaojun Qin, Lei Liu, Hongxiang Lou*, Manganese dioxide-methanesulfonic acid promoted direct dehydrogenative alkylation of sp3 C-H bonds adjacent to a heteroatom,Journal of Organic Chemistry,2013, 78 (7): 3104-3112
9. Juan Jiang#,Bin Sun#, Yanyan Wang, Min Cui, Li Zhang, Changzhi Cui, Yanfeng Wang, Xigong Liu, Hongxiang Lou*, Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents,Bioorganic & Medicinal Chemistry,2012, 20 (7): 2382-2391
10. Guangmin Xi#,Bin Sun#, HuiHui Jiang, Feng Kong, Huiqing Yuan, Hongxiang Lou*, Bisbibenzyl derivatives sensitize vincristine- resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity,Bioorganic & Medicinal Chemistry,2010, 18 (18): 6725-6733
11.Bin Sun, Juma Hoshino, Katie Jermihov, Laura Marler, John M. Pezzuto, Andrew D. Mesecar, Mark Cushman, Synthesis, and Biological Evaluation of Resveratrol Analogues as Aromatase and Quinone Reductase 2 Inhibitors for Chemoprevention of Cancer,Bioorganic & Medicinal Chemistry,2010, 18 (14): 5352-5366
12.Bin Sun, Huiqing Yuan, Guangmin Xi, Yudao Ma*, Hongxiang Lou*, Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives,Bioorganic & Medicinal Chemistry,2009, 17 (14): 4981-4989
