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科学研究

副研究员

孙凤

日期:2024-02-26点击:

孙凤 博士 副研究员

电话:0532-58631418

Email: fengsun@sdu.edu.cn

山东省青岛市即墨区滨海大道72号山东大学(青岛)淦昌苑F208


教育经历

(1) 2015-09 2020-06, 山东大学, 有机化学, 博士

(2) 2011-09 2015-06, 济宁医学院, 生物技术, 学士


工作经历

(1) 2020-07 至 2023-07,山东大学国家糖工程技术研究中心, 博士后

(2) 2023-07 至今山东大学国家糖工程技术研究中心, 副研究员


研究方向

1. 蛋白质、多肽药物的化学修饰。

2. 高效肿瘤靶向及抗转移递药系统的研究:

(1) 肿瘤微环境调控纳米递药系统

(2) 多位点抗肿瘤转移纳米递药系统


近五年主持或参加的其他科研项目/课题

(1) 山东省科技厅,省部级,ZR2022QH134,无抗凝活性肝素(GSHP)与抗新生血管生成肽ES2和维生素E 琥珀酸酯为基础的壳核纳米粒用于增强黑色素瘤的靶向治疗,2023-01 2025-1215万元,在研,主持

(2) 山东省科技厅,省部级,YDZX20203700003963 抗肿瘤糖肽的制备和生物活性研究及在医药领域的开 发应用2020-10 2022-1237.5万元,结题,参与

(3) 山东省自然科学基金委,省部级,ZR2019MH023,多靶点抗新生血管生成肽ES2-AF及其体外透明质酸化 修饰肽的抗肿瘤作用机制研究,2019-07 2022-06 20万元, 结题,参与

(4) 山东省科技厅,省部级, 2021CXGC010501骨质疏松症新靶点和疗效评估新技术研究与应用 2022-01 2024-12 82万元, 在研, 参与


代表性研究成果和学术奖励情况

一、代表性论著:

(1) Feng Sun#, Huiwen Hou#, Yan Li, Wen Tang, Jie Wang, Lu Lu, Jiaai Fu, Zengmei Liu, Didi Gao, Feiyan Zhao, Xinqing Gao, Peixue Ling, Fengshan Wang, Haining Tan*. Glycol-split heparin-linked prodrug nanoparticles target the mitochondrion apparatus for cancer metastasis treatment. Small, 2206491. (SCI收录,1区,IF=13.30)

(2) Feng Sun#, Yang Yu#, Zhifang Yang#, Zhendong Wang, Yan Li, Fengshan Wang, and Haining Tan*. Hyaluronic acid-endostatin2-alft1 (HA-ES2-AF) nanoparticle-like conjugate for the target treatment of diseases. Journal of Controlled Release, 288,1-13, 2018. 1. (SCI收录,1区,IF=11.467)

(3) Yan Li, Huiwen Hou, Zengmei Liu, Wen Tang, Jie Wang, Lu Lu, Jiaai Fu, Didi Gao, Feiyan Zhao, XinQing Gao, Peixue Ling, Fengshan Wang, Feng Sun*, and Haining Tan*. CD44 targeting nanodrug based on chondroitin sulfate for melanoma therapy by inducing mitochondrial apoptosis pathways. Carbohydrate Polymers, 2023, 320, 121255. (SCI收录,1区,IF=10.723)

(4) Tang wen, Juan Wang, Huiwen Hou, Yan Li, Jie Wang, Jiaai Fu, Lu Lu, Didi Gao, Zengmei Liu, Feiyan Zhao, Xinqing Gao, Peixue Ling, Fengshan Wang, Feng Sun*, Haining Tan*. Review: Application of chitosan and its derivatives in medical materials. International Journal of Biological Macromolecules, 2023, 240, 124398. (SCI收录,1区,IF=8.2)

(5) Feng Sun, Zhendong Wang, Zhifang Yang, Yan Li, Huifei Cui, Chunhui Liu, DezongGao, Fengshan Wang, and Haining Tan*. Characterization, bioactivity and pharmacokinetic study of a novel carbohydrate-peptide polymer: glycol-split heparin-endostatin2 (GSHP-ES2). Carbohydrate Polymers, 207, 79-90, 2019. 2. (SCI收录,1区,IF=10.723)

(6) Liang Xing#, Feng Sun#, Zhendong Wang, Yan Li, Zhifang Yang, Fengshan Wang, and Haining Tan*. Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate. International Journal of Nanomedicine, 14, 2573–2589, 2019.  (SCI收录,1区,IF=7.033)

(7) Feng Sun#, Abdul Sami Shaikh#, Juan Wang, Hui Gao, Zhifang Yang, Zhendong Wang, Yan Li, Fengshan Wang, and Haining Tan*. Higher Anti-angiogenesis Activity, Better Cellular Uptake and Longer Half-life of a Novel Glyco-modified Endostatin by Polysulfated Heparin. Current Pharmaceutical Biotechonology,  19(12): 996 - 1004, 2018. (SCI收录,4区,IF=2.829)

(8) Huiwen Hou, Juan Wang, Jie Wang, Wen Tang, Abdul Sami Shaikh, Yan Li, Jiaai Fu, Lu Lu, Fengshan Wang, Feng Sun*, and Haining Tan*. A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications. Journal of Biomedical Nanotechnology, 16, 1687–1718, 2020. (SCI收录,3区,IF=3.641)

(9) Yang Yu#, Feng Sun#, Congcong Zhang#, Zhendong Wang, Jinfeng Liu, and Haining Tan*. Study on glyco-modification of endostatin-derived synthetic peptide endostatin2 (ES2) by soluble chitooligosaccharide. Carbohydrate Polymers, 154, 204-213, 2016. (SCI收录,1区,IF=10.723)

(10) Zhifang Yang, Yan Li, Feng Sun, Huiwen Hou, Liang Xing, Zhendong Wang, FengshanWang, Haining Tan*. Improved stability and enhanced anti-tumor activity of hyaluronic acid modified ES2-AF nanoparticle-like conjugate. Journal of Biomedical Nanotechnology, 15, 1781–1791, 2019. (SCI收录,3区,IF=3.641)

(11) Zhendong Wang, Yan Li, Liang Xing, Feng Sun, Zhifang Yang, Fengshan Wang, and Haining Tan*. Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mice. Carbohydrate Polymers, 208, 302-313, 2019. (SCI收录,1区,IF=10.723)

二、论著之外的代表性研究成果和学术奖励

(1) 谭海宁;孙凤;王洁;李妍; 侯慧文;唐雯; 卢鲁;符家爱; 高迪迪;刘增美;一种阿特珠单抗-MMAD结合物及其制备方法与应用,2024-02-02 中国, ZL 202210982681.0 (专利,授权)

(2) 谭海宁;凌沛学;孙凤;李妍;侯慧文;王洁; 唐雯; 卢鲁;符家爱; 高迪迪;刘增美;甘油葡萄糖苷-超氧化物歧化酶偶联物及其制备方法、应用,2023-11-24 中国, ZL 202111581277.4 (专利,授权)

(3) 谭海宁;凌沛学;孙凤;翟光喜;刘元秀;李妍;侯慧文;王洁; 唐雯; 卢鲁;符家爱;透明质酸-ES2-AF肽偶联物及其制备方法和应用,2023-07-28 中国, ZL 202110961783.X (专利,授权)

(4) 谭海宁;孙凤;王洁;侯慧文;李妍; 唐雯; 卢鲁;符家爱; 一种透明质酸-超氧化物歧化酶结合物及其在皮肤护理产品中的应用,2021-07-22 中国, ZL 202110830157.7 (专利,授权)

(5) 谭海宁;孙凤;侯慧文;唐雯;王洁;李妍;卢鲁;符家爱;一种硫酸软骨素化ES2肽联合紫杉醇的结合物及其制备方法与应用;国家发明专利;ZL 202110362870.3  (专利,授权)

(6) 谭海宁;姬胜利;孙凤;唐雯;李妍;侯慧文;王洁;卢鲁;符家爱;刘增美;高迪迪;胆酸-季铵化壳寡糖-ES2/喜树碱结合物的制备方法及应用;国家发明专利;ZL 202111524630.5 (专利,授权)

(7) 谭海宁; 于洋; 孙凤 邢亮; 杨志芳; 王振东; 一种新生血管生成抑制肽及其透明质酸修饰物的制备方法与应用;2020-05-22;中国;ZL 201710432512.9 (专利,授权)

(8) 谭海宁; 王娟;张丛丛;刘纯慧;于洋;孙凤 一种 ES-2 肽的季铵化壳寡糖修饰物及其制备方法与应用,2019-01-18,中国, ZL 201610144349.1. (专利,授权)

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