陈宗刚 博士

副教授 硕士生导师

电话：0532-58631407

E-mail：chenzg@sdu.edu.cn

地址：山东省青岛市即墨滨海路72号山东大学青岛校区淦昌苑F楼115室

教育经历

2004.09 - 2008.01东华大学 化学化工与生物工程学院 博士

2006.06 - 2006.09新加坡国立大学 工程学院生物工程系 合作研究

2001.09 - 2004.03天津工业大学 硕士

工作经历

2010.10 至今 山东大学国家糖工程技术研究中心 副教授

2008.09–2010.9   清华大学 材料系 博士后

1995.01–2001.07  山东泰山制丝有限公司

研究方向

生物材料，组织工程，再生医学，药物载体，医美水凝胶

主要是在分析生物材料微组装、生物功能及形成机理的基础上，发展用于人体组织器官修复与替代的新型医学材料，靶向控释给药系统和医美水凝胶。

当前主要工作：

1.仿生材料用于骨和软骨修复再生的研究

2.组织工程小血管的研究

3.仿生皮肤的研究与开发

4.生物人工胰腺的研究

5.可注射水凝胶敷料的研究与开发

6.可注射医美水凝胶的研究

7.药物靶向递送控释材料的研究

主持和参与的项目

1.山东省自然科学基金，ZR2023ME164, 糖基化矿化胶原-壳聚糖仿生骨修复材料成骨和血管化潜能及其机制研究, 2024.01-2026.12, 主持

2.山东省重点研发计划，2017GSF18119，肿瘤靶向性透明质酸寡糖修饰的壳聚糖微球药物载体的制备及性能研究，2017.07-2019.12,主持

3.山东省自然科学基金，ZR2016EMM15，透明质酸寡糖修饰的胶原蛋白纳米纤维仿生细胞外基质及其用于组织工程小血管构建的研究，2016.10-2019.06，主持

4.国家自然科学基金面上项目，21472114，新型细菌成孔毒素抑制剂的设计、合成与活性评价，2015.01-2018.12，参加

5.山东大学基本科研业务费资助项目—交叉学科培育项目，2015JC004，基于糖基化胶原仿生细胞外基质的组织工程小血管的构建，2015.01-2017.12，主持

6．山东省科技发展计划，2014GSF118113，基于糖基化修饰的矿化胶原仿生骨修复材料分级自组装，2014.01-2016.12，主持

7．山东省自然科学基金面上项目，ZR2012EMM008，基于蛋白-多糖纳米纤维多层仿生细胞外基质支架的组织工程小血管的体外构建，2012.08-2015.07，主持

8．山东大学自主创新基金，2010TB011，微创原位自固化可注射仿生骨修复材料的研究，2010.10-2012.12，主持

9．国家自然科学基金面上项目，50973052、神经干细胞的支架材料研究,2010.01-2012.12，参加

10．中国博士后基金一等资助项目，20100470011，从纳米到厘米-骨再生植入材料的多级结构仿生研究，2009.10-2010.10，主持

11．国家863计划项目，2008AA03Z305、蛋白－多糖复合纳米纤维用于组织修复的研究，2008.09-2012.12，参加

12．国家自然科学基金面上项目，30570503，胶原蛋白-甲壳胺复合纳米纤维仿生组织细胞间质及与细胞相互作用的研究，2006.1-2008.12，参加

13.企业横向课题，主持“仿生骨软骨修复材料的研究与开发”，“医用可吸收生物材料性能评价研究”，“人工骨修复材料”，“医用羧甲基壳聚糖凝胶（关节腔内注射用）体外降解研究与开发”等多项企业委托课题。

代表论文

1. Weibin Jia, Runrun Li, Fengjuan Zou, Min Li, Hongjuan Weng, Qianqian Shen, Guozhen Qi, Ruipiao Zhou, Yikang Shi, Guofeng Gu, Fengshan Wang, Zonggang Chen*. Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics. Advanced Healthcare Materials. 2024, 13, 2402158.

2.Yuanmeng Zhou, Weibin Jia; Jiexue Bi; Meng Liu; Liling Liu; Hang Zhou; Guofeng Gu; Zonggang Chen*. Sulfated hyaluronic acid/collagen-based biomimetic hybrid nanofiber skin for diabetic wound healing: Development and preliminary evaluation. Carbohydrate Polymers. 2024, 334: 122025.

3. Weibin Jia, Liling Liu, Min Li, Yuanmeng Zhou, Hang Zhou, Hongjuan Weng, Guofeng Gu, Min Xiao, Zonggang Chen*. Construction of enzyme-laden vascular scaffolds based on hyaluronic acid oligosaccharides-modified collagen nanofibers for antithrombosis and in-situ endothelialization of tissue-engineered blood vessels. Acta Biomaterialia, 2022, 153: 287-298.  

4. Hongjuan Weng, Weibin Jia, Min Li, Zonggang Chen*. New injectable chitosan-hyaluronic acid based hydrogels for hemostasis and wound healing. Carbohydrate Polymers, 2022, 294: 119767.

5. Liling Liu, Weibin Jia, Yuanmeng Zhou, Hang Zhou, Meng Liu, Min Li, Xiuli Zhang, Guofeng Gu, Zonggang Chen*. Hyaluronic acid oligosaccharide-collagen mineralized product and aligned nanofibers with enhanced vascularization properties in bone tissue engineering. International Journal of Biological Macromolecules, 2022, 206: 277-287.

6. Weibin Jia, Min Li, Liling Liu, Hang Zhou, Xiankun Liu, Guofeng Gu, Min Xiao, Zonggang Chen*. Fabrication and assessment of chondroitin sulfate-modified collagen nanofibers for smalldiameter vascular tissue engineering applications. Carbohydrate Polymers, 2021, 257: 117573.

7. Min Li, Weibin Jia, Xiuli Zhang, Hongjuan Weng, Guofeng Gu, Zonggang Chen*. Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering. Carbohydrate Polymers, 2021, 260: 117780.

8. Weibin Jia, Min Li, Hongjuan Weng, Guofeng Gu, Zonggang Chen*. Carbohyd Polym. Design and comprehensive assessment of a biomimetic tri-layer tubular scaffold via biodegradable polymers for vascular tissue engineering, Materials Science & Engineering C-Materials for Biological Applications, 2020, 110: 110717.

9. Min Li, Xiuli Zhang, Weibi Jia, Qin Wang, Yang Liu, Xianpeng Wang, Chuandong Wang, Jianjun Jiang, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Improving in vitro biocompatibility on biomimetic mineralized collagen bone materials modified with hyaluronic acid oligosaccharide. Materials Science & Engineering C-Materials for Biological Applications, 2019, 104: 110008.

10. Lingzhi Kang, Weibin Jia, Min Li, Qin Wang, Chuandong Wang, Yang Liu, Xianpeng Wang, Lan Jin, Jianjun Jiang, Guofeng Gu, Zonggang Chen*. Hyaluronic acid oligosaccharide-modified collagen nanofibers as vascular tissue-engineered scaffold for promoting endothelial cell proliferation, Carbohydrate Polymers, 2019, 223: 115106.

11. Weibin Jia, Min Li, Lingzhi Kang, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Fabrication and Comprehensive Characterization of Biomimetic Extracellular Matrix Electrospun Scaffold for Vascular Tissue Engineering Applications. Journal of Materials Science, 2019, 54(15): 10871-10883.

12. Fengjuan Zou#, Runrun Li#, Jianjun Jiang, Xiumei Mo, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Mechanical enhancement and in vitro bicompatibility of nanofibrous collagen-chitosan scaffolds for tissue engineering. Journal of Biomaterials Science: Polymer Edition, 2017, 28(18): 2255-227.

13. Siqiang Li, Hong Wang, Juncai Ma, Guofeng Gu*,Zonggang Chen*, and Zhongwu Guo*. One-pot four-enzyme synthesis of thymidinediphosphate-L-rhamnose. Chemical Communications, 2016, 52(97): 13995-13998.

14. Xin Zhao, Zonggang Chen*, Guofeng Gu, Zhognwu Guo *. Recent advances in the research of bacterial glucuronosyltransferases. Journal of Carbohydrate Chemistry, 2016, 35(4): 201-223.

15. Zonggang Chen#*, Xiuli Zhang#, Lingzhi Kang#, Fei Xu, Zhaoling Wang, Fuzhai Cui, Zhongwu Guo. Recent progress in injectable bone repair materials research. Frontiers of Materials Science, 2015, 9(4): 332-345.

16. Zonggang Chen*, Lingzhi Kang, Qing-Yuan Meng, Huanye Liu, Zhaoling Wang, Zhongwu Guo*, Fuzhai Cui*. Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration. Materials Science & Engineering C-Materials for Biological Applications, 2014, 45(1): 94-102.

17. Zonggang Chen*, Lingzhi Kang, Zhaoling Wang, Fei Xu, Guofeng Gu, Fuzhai Cui, Zhongwu Guo*. Recent progress in the research of biomaterials regulating cell behavior. RSC Advances, 2014, 4(109): 63807-63816.

18. Zonggang Chen*, Huanye Liu, Xi Liu, Xiaojie Lian, Fuzhai Cui*. Improved Workability of Injectable Calcium Sulfate Bone Cement by Regulation of Self-setting Properties. Materials Science & Engineering C-Materials for Biological Applications, 2013, 33(3): 1048-1053.

19. Ning-Min Hu#, Zonggang Chen#, Xi Liu, Huanye Liu, Xiaojie Lian, Xiumei Wang, Fu-Zhai Cui. Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sulfate/nano-HA/collagen bone graft substitute. Journal Of The Mechanical Behavior Of Biomedical Materials, 2012, 12: 119-128.

20. Zonggang Chen*, Huanye Liu, Xi Liu and Fu-Zhai Cui. Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties. Journal Of Biomedical Materials Research Part A, 2011, 99A (4): 554-563.

21. Zonggang Chen, Peiwei Wang, Bo Wei, Xiumei Mo, Fu-zhai Cui. Electrospun collagen-chitosan nanofiber: a biomimetic extracellular matrix for endothelial cell and smooth muscle cell. ACTA Biomaterialia, 2010, 6 (2): 372-382.

22. Xi Liu, Xiumei Wang, Zonggang Chen, Fuzhai Cui. Huan-Ye Liu, Keya Mao, Yan Wang Injectable bone cement based on mineralized collagen. Journal Of Biomedical Materials Research Part B. 2010, 94B (1):72-79.

23. Zonggang Chen, Bo Wei, Xiumei Mo, C.T. Lim, Seeram Ramakrishna, Fu-zhai Cui. Mechanical Properties of Electrospun Collagen-Chitosan Complex Single Fibers and Membrane. Materials Science & Engineering C-Materials for Biological Applications, 2009, 29 (8): 2428-2435.

24. Zonggang Chen, Bo Wei, Xiumei Mo, Fu-zhai Cui. Diameter control of electrospun chitosan-collagen fibers. Journal Of Polymer Science Part B-polymer Physics, 2009, 47 (19): 1949-1955.

25. Zonggang Chen, Xiumei Mo. Intermolecular interactions in electrospun collagen -chitosan complex nanofibers. Carbohydrate Polymers, 2008, 72 (3): 410–418.

26. Zonggang Chen, Xiumei Mo, Fengling Qing. Electrospinning of Collagen-Chitosan Complex. Materials Letters, 2007, 61 (16): 3490–3494.

授权专利

1.陈宗刚，翁洪娟，贾维彬，顾国锋.一种力学性能可调的可注射自愈合水凝胶及其制备方法与应用. 中国发明专利：ZL202010436742.4

2.陈宗刚,贾维彬,康灵芝.一种透明质酸寡糖修饰的胶原蛋白纳米纤维血管修复材料及其制备方法.中国发明专利：ZL201711075437.1

3.陈宗刚,栗敏,张秀丽,顾国锋.一种仿生糖基化矿化胶原/糖基化壳聚糖/PLGA复合骨组织工程支架及其制备方法.中国发明专利：ZL201910202984.4

4.陈宗刚,张秀丽,栗敏,顾国锋.一种透明质酸寡糖修饰的矿化胶原仿生骨修复材料及其制备方法.中国发明专利：ZL201710192690.9

5.陈宗刚,张秀丽,栗敏,顾国锋.一种透明质酸寡糖修饰的矿化胶原仿生骨修复材料. 中国发明专利：ZL201910940492.5

6.陈宗刚，邹凤娟，顾国峰.一种包载多西紫杉醇的透明质酸寡糖-壳聚糖微球及其制备方法与应用. 中国发明专利：ZL201810348940.8

7.陈宗刚,李润润,翁洪娟,顾国锋. 基于静电喷射的透明质酸寡糖修饰的靶向纳米药物载体及其制备方法和应用.中国发明专利：ZL201910216522.8

8.陈宗刚，莫秀梅.中国发明专利：胶原蛋白和壳聚糖复合纳米纤维静电纺丝的制备方法. 中国发明专利：ZL 200610116988.3

获奖和名誉

1. 2015-2020 连续入选“中国高被引学者”榜单。

2. 2008年12月，水溶性医用几丁糖的制备技术及应用，获“上海市技术发明奖”一等奖。