高健 博士
教授 博士生导师
山东省青岛市即墨区滨海路72号
山东大学青岛校区淦昌苑F-128室
电话：0532-58631410
E-mail: jgao@sdu.edu.cn
工作与学习经历：
2016.04-至今，山东大学，国家糖工程技术研究中心，依次评聘为研究员、教授
2012.06-2016.04，美国韦恩州立大学，化学系，博士后，合作导师：郭忠武教授
2006.09-2012.06，山东大学，药学院，医学硕士、医学博士，导师：娄红祥教授
2001.09-2006.06，泰山医学院（现山东第一医科大学），药学院，医学学士
研究方向：
1. 针对强耐药性细菌感染开展新型糖疫苗研究
2. 围绕能源、环境和生命健康等领域开展新型功能材料研究
3. 生物活性分子全合成及合成方法学研究
主持科研项目：
1. 国家自然科学基金面上项目
2. 国家自然科学基金青年项目
3. 山东省自然科学基金面上项目
4. 山东省重点研发计划项目
5. 山东大学青年学者未来计划项目
6. 企业横向课题
发表论文：
1. Xiaoyu Yang, Han Zhang, Qingpeng Zhao, Qingjiang Li, Tiehai Li, Jian Gao.* Total synthesis of the repeating units of highly functionalized O-antigens of Pseudomonas aeruginosa ATCC 27577, O10, and O19. JACS Au, 2024, 4, 2351-2362.
2. Qingpeng Zhao, Shihao Zhou, Yue Wang, Xiaoyu Yang, Youhui Meng, Yanxin Zhang, Jian Gao.* Stereoselective synthesis of the 3,6-branched Fuzi a-glucans up to 15-mer via a one-pot and convergent glycosylation strategy. Chinese Chemical Letters. 2023, 34, 107982.
3. Han Zhang, Aoxin Guo, Youhui Meng, Yue Wang, Jian Gao,* and Xue-Wei Liu.* Stereodirecting effects of 4-O-ortho-cyanobenzyl ether on chemical glycosylation with glucopyranosyl donor. Chinese Journal of Chemistry. 2023, 41, 651-656.
4. Han Zhang, Xiaohan Wang, Youhui Meng, Xiaoyu Yang, Qingpeng Zhao, Jian Gao.* Total synthesis of the tetrasaccharide haptens of Vibrio vulnificus MO6-24 and BO62316 and immunological evaluation of their protein conjugates. JACS Au, 2022, 2, 97-108.
5. Yanxin Zhang, Han Zhang, Ying Zhao, Zhongwu Guo, Jian Gao.* Efficient strategy for α-selective glycosidation of D-glucosamine and its application to the synthesis of a bacterial capsular polysaccharide repeating unit containing multiple α-linked GlcNAc residues. Organic Letters, 2020, 22, 1520-1524.
6. Qingpeng Zhao, Han Zhang, Yanxin Zhang, Shihao Zhou, Jian Gao.* Stereoselective synthesis of a branched α-decaglucan. Organic & Biomolecular Chemistry, 2020, 18, 6549-6557.
7. Han Zhang, Liming Shao, Xiaohan Wang, Yanxin Zhang, Zhongwu Guo,* Jian Gao.* One-pot synthesis of the repeating unit of type VII group B Streptococcus polysaccharide and the dimer. Organic Letters, 2019, 21, 2374-2377.
8. Yanxin Zhang, Shihao Zhou, Xiaohan Wang, Han Zhang, Zhongwu Guo,* Jian Gao.* A new method for α-specific glucosylation and its application to the one-pot synthesis of a branched α-glucan. Organic Chemistry Frontiers, 2019, 6, 762-772.
9. Han Zhang, Shihao Zhou, Ying Zhao, Jian Gao.* Chemical synthesis of the dimeric repeating unit of type Ia group B Streptococcus capsular polysaccharide. Organic & Biomolecular Chemistry, 2019, 17, 5839-5848.
10. Liming Shao, Han Zhang, Yaoyao Li, Guofeng Gu, Feng Cai, Zhongwu Guo,* Jian Gao.* Chemical synthesis of the repeating unit of type II group B Streptococcus capsular polysaccharide. The Journal of Organic Chemistry, 2018, 83, 5920-5930.
11. Jian Gao, Zhongwu Guo. Progress in the synthesis and biological evaluation of lipid A and its derivatives. Medicinal Research Reviews, 2018, 38, 556-601.
12. Jian Gao, Zhifang Zhou, Jiatong Guo, Zhongwu Guo. Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins. Chemical Communications, 2017, 53, 6227-6230.
13. Jian Gao, Zhongwu Guo. Synthetic studies of GPI-anchored peptides, glycopeptides, and proteins. RSC Chemical Biology of Glycoproteins, Editor: Zhongping Tan, Lai-Xi Wang. 2017, 253-281.
14. Jian Gao, Zhongwu Guo. Chemical synthesis of the repeating unit of type V group B Streptococcus capsular polysaccharide. Organic Letters, 2016, 18, 5552-5555.
15. Lili Lu,# Jian Gao,# Zhongwu Guo. Labeling cell surface GPIs and GPI-anchored proteins through cell metabolic engineering with artificial inositol derivatives. Angewandte Chemie International Edition, 2015, 54, 9679-9682.
16. Jian Gao, Guochao Liao, Lizhen Wang, Zhongwu Guo. Synthesis of a miniature lipoarabinomannan. Organic Letters, 2014, 16, 988-991.
17. Xin Zan,# Jian Gao,# Guofeng Gu, Shanshan Liu, Bin Sun, Lei Liu, Hong-Xiang Lou. Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1600-1604.
18. Jian Gao, Zhongwu Guo. Synthesis of a tristearoyl lipomannan via preactivation-based iterative glycosylation. The Journal of Organic Chemistry, 2013, 78, 12717-12725.
19. Jian Gao, Zhongwu Guo. Recent progress in the synthesis of GPIs and GPI-anchored proteins. SCIENTIA SINICA Chimica. 2013, 43, 964-983.
20. Jian Gao, Xia Li, Guofeng Gu, Shanshan Liu, Min Cui, Hong-Xiang Lou. Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 2396-2400.
21. Jian Gao, Xia Li, Guofeng Gu, Bin Sun, Min Cui, Mei Ji, Hong-Xiang Lou. Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis. Bioorganic & Medicinal Chemistry Letters, 2011, 21, 622-627.
22. Yanyan Wang,# Jian Gao,# Guofeng Gu, Gang Li, Changzhi Cui, Bin Sun, Hong-Xiang Lou. In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides. ChemBioChem. 2011, 12, 2418-2420.
23. Jian Gao, Xia Li, Beibei Lv, Bin Sun, Changjun Zhu, Hong-Xiang Lou. LC-DAD/MS/MS detection of macrocyclic bisbibenzyls from the liverwort Reboulia hemisphaerica and the cell-based screening of their microtubule inhibitory effects. Chinese Journal of Natural Medicines, 2009, 7, 123-128.
