Education

Research Experience

Research Interests

· Preparation of oligosaccharides and glycoconjugates

· Chemical biology of protein glycosylation

Representative Publications

· Tong, Li‖;Tianlu, Li‖; Haoru, Zhuang; Fengshan, Wang; Richard, R. Schmidt; Peng, Peng, O-Glycosyl Trichloroacetimidates as Glycosyl Donors and Platinum(IV) Chloride as a Dual Catalyst Permitting Stereo- and Regioselective Glycosidations. ACS Catalysis 2021, 11, 10279-10287.(‖equal contribution)

· Tianlu, Li,* Tong Li, Yajing Sun, Yue Yang, Panpan Lv, Fengshan Wang, Hongxiang Lou, Richard R. Schmidt* and Peng Peng* Regioselective Benzoylation of Unprotectedβ-Glycopyranosides with Benzoyl Cyanide and an Amine Catalyst–Application to Saponin Synthesis, Organic Chemistry Frontiers 2021, 8, 260-265.

· Tianlu, Li‖; Tong, Li‖; Michael, Linseis‖; Fengshan, Wang; Rainer, F. Winter; Richard, R. Schmidt; Peng, Peng, Catalytic Regioselective Benzoylation of 1,2-trans-Diols in Carbohydrates with Benzoyl Cyanide: The Axial Oxy Group Effect and the Action of Achiral and Chiral Amine Catalysts. ACS Catalysis 2020,10, 11406-11416. (‖equal contribution)

· Tianlu, Li; Weizhun, Yang; Sherif, Ramadan; Xuefei, Huang* Synthesis of O-Sulfated Human Syndecan-1-like Glyco-polypeptides by Incorporating Peptide Ligation and O-Sulfated Glycopeptide Cassette Strategies. Organic Letters 2020, 22, 6429-6433.

· Aiman Saleh A. Mohammed; Weilu, Tian; Youqin, Zhang; Peng, Peng; Fengshan, Wang*; Tianlu, Li* Leishmania lipophosphoglycan components: A potent target for synthetic neoglycoproteins as a vaccine candidate for leishmaniasis. Carbohydrate Polymers 2020, 237, 116120.

· Tong, Li‖;Tianlu, Li‖; Tongxiao, Cui; Yajing, Sun; Fengshan, Wang; Hongzhi, Cao; Richard, R. Schmidt*; Peng, Peng* Regioselective One-Pot Benzoylation of Triol and Tetraol Arrays in Carbohydrates.Organic Letters 2018, 20, 3862-3865. (‖equal contribution)

· Tianlu, Li; Heng, Liu; Xuechen, Li* Chemical Synthesis of HMGA1a Proteins with Post-translational Modifications via Ser/Thr Ligation Organic Letters 2016, 18, 5944-5947.

· Sherif, Ramadan; Tianlu, Li; Weizhun, Yang; Jicheng, Zhang; Zahra, Rashidijahanabad; Zibin, Tan; Narayanan, Parameswaran; Xuefei, Huang* Chemical Synthesis and Anti-Inflammatory Activity of Bikunin Associated Chondroitin Sulfate 24-mer. ACS Central Science 2020, 6, 913-920.

· Kang, Jin; Tianlu, Li; Hoi Yee, Chow; Han, Liu; Xuechen, Li* P−B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site‐Specific Deuteration Angewandte Chemie International Edition2017, 56, 14607-14611.

· Xiaoju Zheng, Lin Zhu, Tianlu Li, Wenjia Xu, Dongke Liu, Juzheng Sheng, Hongzhi Cao, Yikang Shi, Fengshan Wang*. Improve Stability of Bioactive Peptides by Enzymatic Modular Synthesis of Peptides with O-Linked Sialyl Lewis x. ACS Catalysis, 2021, 11, 8042-8048.

· Mingyue, Liu; Ming-De, Li*; Jinqing, Huang; Tianlu, Li; Han, Liu; Xuechen, Li; David Lee Phillips* Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions Scientific Report2016, 6, 21606.

· Jonghan Peter, Lee; Changdong, Liu;Tianlu, Li; Guang, Zhu*; Xuechen,Li* Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction Journal of Peptide Science2015, 21, 593-598.

· Clarence, T. T. Wong;Tianlu, Li; Hiu Yung, Lam; Yinfeng, Zhang; Xuechen, Li* Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof Frontiers in Chemistry2014, 2.

· Yinfeng, Zhang; Tianlu, Li; Xuechen, Li* Synthesis of human growth hormone releasing hormone via three-fragment serine/threonine ligation (STL) Organic and Biomolecular Chemistry2013, 11, 5584-5587.

Honors and Awards

· Certificate of Teaching and Learning in Higher Education, 2012, The University of Hong Kong

· Postgraduate Research Seminar Award, 2015, The University of Hong Kong

Patents

· 一种糖苷化反应催化剂、糖苷化方法和应用，国家发明专利，202110864797X

· 一种N-乙酰基-L-酪氨酰-L-精氨酸十六烷基酯的合成方法，国家发明专利，2021102114492

· 一种茶叶香料前体糖苷及其合成方法，国家发明专利，2020102370352

· 一种O‐甘露聚糖核心结构的合成方法，国家发明专利，ZL201910309945.4