|
Name: Jian Gao |
Tel: 0532-58631410 |
Title: Professor |
Supervisor: Master advisor |
E-mail: jgao@sdu.edu.cn |
Address: 72 Binhai Road, Qingdao, Shandong Province, China |
Education
Degree |
Date |
Affiliation |
Major |
PhD |
2009.9-2012.6 |
Shandong University |
Pharmaceutical chemistry |
Master |
2006.9-2009.7 |
Shandong University |
Pharmaceutical chemistry |
Bachelor |
2001.9-2006.7 |
Shandong First Medical University |
Pharmacy |
Research Experience
Date |
Affiliation |
Position |
2012.6-2016.4 |
Wayne State University |
Postdoctor fellow |
2016.4-present |
Shandong University |
Professor |
Research Interests
1. Highly efficientand novel methodology for carbohydrate chemistry.
2. Chemical synthesis of complex oligosaccharides and glycoconjugates withpotential biological activities.
3. Antibacterial glycoconjugate vaccines.
Representative Publications
1. Yanxin Zhang, Han Zhang, Ying Zhao, Zhongwu Guo,Jian Gao.* Efficient strategy fora-selective glycosidation ofD-glucosamine and its application to the synthesis of a bacterial capsular polysaccharide repeating unit containing multiplea-linked GlcNAc residues.Organic Letters, 2020, 22, 1520-1524.
2. Qingpeng Zhao, Han Zhang, Yanxin Zhang, Shihao Zhou,Jian Gao.* Stereoselective synthesis of a brancheda-decaglucan.Organic & Biomolecular Chemistry,2020, 18, 6549-6557.
3. Han Zhang, Liming Shao, Xiaohan Wang, Yanxin Zhang, Zhongwu Guo,*,# Jian Gao.*,# One-pot synthesis of the repeating unit of type VII group BStreptococcus capsular polysaccharide and the dimer.Organic Letters, 2019, 21, 2374-2377.
4. Han Zhang, Shihao Zhou, Ying Zhao,Jian Gao.* Chemical synthesis of the dimeric repeating unit of type Ia group BStreptococcus capsular polysaccharide.Organic & Biomolecular Chemistry,2019, 17, 5839-5848.
5. Yanxin Zhang, Shihao Zhou, Xiaohan Wang, Han Zhang, Zhongwu Guo,*,# Jian Gao.*,# A new method for α-specific glucosylation and its application to the one-pot synthesis of a branched α-glucan. Organic Chemistry Frontiers, 2019,6, 762-772.
6. Liming Shao, Han Zhang, Yaoyao Li, Guofeng Gu, Feng Cai, Zhongwu Guo,*,# Jian Gao.*,# Chemical synthesis of the repeating unit of type II group BStreptococcus capsular polysaccharide. The Journal of Organic Chemistry, 2018,83, 5920-5930.
7. Jian Gao, Zhongwu Guo. Progress in the synthesis and biological evaluation of lipid A and its derivatives.Medicinal Research Reviews,2018, 38, 556-601.
8. Jian Gao, Zhongwu Guo. Synthetic studies of GPI-anchored peptides, glycopeptides, and proteins. RSC Chemical Biology of Glycoproteins, Editor: Zhongping Tan, Lai-Xi Wang.2017, 253-281.
9. Jian Gao, Zhifang Zhou, Jiatong Guo, Zhongwu Guo. Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins. Chemical Communications, 2017, 53, 6227-6230.
10. Jian Gao, Zhongwu Guo. Chemical synthesis of the repeating unit of type V group BStreptococcus capsular polysaccharide.Organic Letters, 2016, 18, 5552-5555.
11. Lili Lu,# Jian Gao,# Z. Guo. Labeling cell surface GPIs and GPI-anchored proteins through cell metabolic engineering with artificial inositol derivatives.Angewandte Chemie International Edition, 2015, 54, 9679-9682.
12. Jian Gao, Guochao Liao, Lizhen Wang, Zhongwu Guo. Synthesis of a miniature lipoarabinomannan.Organic Letters, 2014, 16, 988-991.
13. Xin Zan,# Jian Gao,# Guofeng Gu, Shanshan Liu, Bin Sun, Lei Liu, Hong-Xiang Lou. Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.Bioorganic & Medicinal Chemistry Letters,2014, 24, 1600-1604.
14. Jian Gao, Zhongwu Guo. Synthesis of a tristearoyl lipomannan via preactivation-based iterative glycosylation.The Journal of Organic Chemistry, 2013, 78, 12717-12725.
15. Jian Gao, Xia Li, Guofeng Gu, Shanshan Liu, Min Cui, Hong-Xiang Lou. Facile synthesis of triterpenoid saponins bearingβ-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities.Bioorganic & Medicinal Chemistry Letters, 2012, 22, 2396-2400.
16. Jian Gao, Xia Li, Guofeng Gu, Bin Sun, Min Cui, Mei Ji, Hong-Xiang Lou. Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis.Bioorganic & Medicinal Chemistry Letters, 2011, 21, 622-627.
17. Yanyan Wang,# Jian Gao,# Guofeng Gu, Gang Li, Changzhi Cui, Bin Sun, Hong-Xiang Lou. In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides.ChemBioChem.2011, 12, 2418-2420.
18. Cunxian Duan,# Jian Gao,# Dianrui Zhang, Lejiao Jia, Yue Liu, Dandan Zheng, Guangpu Liu, Xiaona Tian, Fengshan Wang, Qiang Zhang. Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin.Biomacromolecules.2011, 12, 4335-4343.
19. Jian Gao, Xia Li, Beibei Lv, Bin Sun, Changjun Zhu, Hong-Xiang Lou. LC-DAD/MS/MS detection of macrocyclic bisbibenzyls from the liverwortReboulia hemisphaerica and the cell-based screening of their microtubule inhibitory effects.Chinese Journal of Natural Medicines, 2009, 7, 123-128.
