|
Name: Liu, Chang-Cheng |
Tel:+86-532-5863-1415 (O) Fax:+86-532-5863-1405 (O) |
Title: Associate Professor |
E-mail: ccliu@sdu.edu.cn |
Address: National Glycoengineering Research Center, Shandong University, 72 Binhai Road, Qingdao, Shandong 266237, China |
Education
Degree |
Date |
Affiliation |
Major |
PhD |
2016 |
Peking University |
Chemical Biology |
Bachelor |
2010 |
Shandong University |
Pharmaceutical Engineering |
Research Experience
Date |
Affiliation |
Position |
2017.7-present |
National Glycoengineering Research Center, Shandong University |
Research Assistant Professor |
2016.7-2017.6 |
Abace Biotechnology Co. Ltd. |
Research Scientist |
Research Interests
My research interests mainly focus on the development of novel and highly efficient strategies for the synthesis of biologically important glycans. I am also interested to the functional glycomics, carbohydrate-based vaccines, drugs and immunotherapy.
Representative Publications
1. Chang-Cheng Liu, Jinfeng Ye, and Hongzhi Cao.* Chemical Evolution of Enzyme-Catalyzed Glycosylation. Acc. Chem. Res. 2024, 57, 636-647.
2. Lin Yang, Shuaishuai Wang, Changsheng Chen, Chang-Cheng Liu, Xiaoqin Wang, Shuang Li, Yi Li, Peixue Ling, Zhongfu Wang, and Junqiang Fang.* Programmable Enzymatic Toolbox for the Assembly of Fucosylated Chondroitin Derivatives. ACS Catal. 2024, 14, 670-677.
3. Na Lu, Yun Li, Hui Xia, Kan Zhong, Chenning Jia, Jinfeng Ye, Xianwei Liu, Chang-Cheng Liu,* Hongzhi Cao.* A Redox-Controlled Substrate Engineering Strategy for Site-Specific Enzymatic Fucosylation. Angew. Chem. Int. Ed. 2022, e202211032.
4. Chang-Cheng Liu, Chang-Xin Huo, Canjia Zhai, Xiu-Jing Zheng, De-Cai Xiong, and Xin-Shan Ye.* Synthesis and Immunological Evaluation of Pentamannose-Based HIV-1 Vaccine Candidates. Bioconjugate Chem., 2022, 33, 807-820.
5. Wenyuan Fang, Kan Zhong, Jiansong Cheng, Xian-Wei Liu, Chang-Cheng Liu,* Zhongfu Wang, Hongzhi Cao.* Capture-Release Strategy Facilitates Rapid Enzymatic Assembly of Oligosaccharides. Chin. J. Chem., 2022, 40, 343-350.
6. Hui Xia, Jinfeng Ye, Hongzhi Cao, Xianwei Liu, Yan Zhang, and Chang-Cheng Liu.* Enzymatic modular assembly of hybrid Lewis antigens. Org. Biomol. Chem., 2021, 19, 8041-8048
7. Weiying Hong#, Chang-Cheng Liu#, Henan Zhang, Zhiyong Chen, Min Xiao*, and Li Xu.* Cancer Cell Preferential Penetration and pH-Responsive Drug Delivery of Oligorutin. Biomacromolecules, 2021, 22, 9, 3679-3691
8. Kan Zhong, Jinfeng Ye, Xinhao Zhu, Hongzhi Cao, and Chang-Cheng Liu.* Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sda antigens. Green Chem., 2020, 22, 8002-8011.
9. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu,* Lei Li, * Fengshan Wang,* Peixue Ling* and Hongzhi Cao.* Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives. Chem. Commun., 2020, 56, 7549-7552.
10. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao.* Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.
11. Tian Gao#, Jingyu Yan#, Chang-Cheng Liu, Angelina S. Palma, Zhimou Guo, Min Xiao, Xi Chen, Xinmiao Liang, Wengang Chai, and Hongzhi Cao.* Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope. J. Am. Chem. Soc. 2019, 141, 19351-19359.
12. Na Lu#, Jinfeng Ye#, Jiansong Cheng#, Aniruddha Sasmal#, Chang-Cheng Liu, Wenlong Yao, Jun Yan, Naazneen Khan, Wen Yi, Ajit Varki, Hongzhi Cao.* Redox-controlled site-specific α2-6-sialylation. J. Am. Chem. Soc. 2019, 141, 4547-4552.
13. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki, Fengshan Wang,* Hongzhi Cao.* Chemoenzymatic assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018, 57, 9003-9007.
14. Chengcheng Song, Xiujing Zheng, Chang-Cheng Liu, Yifa Zhou, Xinshan Ye.* A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model, Oncotarget, 2017, 8, 47330-47343.
15. Chang-Cheng Liu, Canjia Zhai, Xiujing Zheng, Xinshan Ye.* Altering the specificity of the antibody response to HIV gp120 with a glycoconjugate antigen, ACS Chemical Biology, 2016, 11, 1702-1709.
16. Chang-Cheng Liu, Xiujing Zheng, Xinshan Ye.* Broadly neutralizing antibody-guided carbohydrate-based HIV vaccine design: challenges and opportunities，ChemMedChem，2016, 11, 357-362.
17. Changxin Huo, Xiujing Zheng, An Xiao, Chang-Cheng Liu, Shuang Sun, Zhuo Lv, Xinshan Ye.* Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates, Organic ＆ Biomolecular Chemistry, 2015, 13, 3677-3690.
18. Chang-Cheng Liu, Xinshan Ye.* Carbohydrate-based cancer vaccines: target cancer with sugar bullets, Glycoconjugate Journal, 2012, 29, 259-271.
