王帅帅 研究员

山东省泰山学者青年专家

山东大学齐鲁青年学者

通讯地址：山东省青岛市即墨滨海公路72号山东大学青岛校区K6-204室

办公室电话：(0532)-58631650

邮箱：swang1@sdu.edu.cn

教育经历

2020   Georgia State University    生物化学   理学博士

2015   山东大学   生物化学与分子生物学   理学硕士

2012   西南大学   制药工程   工学学士

工作经历

2023.1-至今   山东大学国家糖工程技术研究中心，研究员

2020.7-2022.12  美国佐治亚州立大学化学系，博士后

研究方向

1. 复杂糖链的酶法高效合成

2. 功能性寡糖库的构建

3. 糖链的构效关系解析

科研项目

1. 国家重点研发计划子课题，2024至2027，在研，主持

2. 山东省优秀青年基金（海外），2023至2025，在研，主持

3. 江苏省自然科学基金青年基金，2022至2024，在研，主持

代表性论文

1. Yinshuang Li; Yi Li; Yuxi Guo; Congcong Chen; Lin Yang; Qian Jiang; Peixue Ling; Shuaishuai Wang;* Lei Li;* Junqiang Fang.* Enzymatic modular synthesis of asymmetrically branched human milk oligosaccharides. Carbohydrate Polymers 2024, 333, 121908.

2. Shuang Li;# Shuaishuai Wang;# Jingyao Qu; Jingjun Han; Lin Yang; Yi Li; Lei Li; Qingwen Jia; Congcong Chen; Peixue Ling; Junqiang Fang.* Programmable One Cycle-One Disaccharide Unit Modular Synthesis of Hyaluronan and Chondroitin Hybrid Glycans. Green Chem. 2023, 25 (5), 2021-2027.

3. Xuefeng Cao;# Shuaishuai Wang;# Madhusudhan Reddy Gadi;# Ding Liu; Peng G Wang; Xiu-Feng Wan; Jian Zhang; Xi Chen; Lauren E Pepi; Parastoo Azadi; Lei Li.* Systematic synthesis of bisected N-glycans and unique recognitions by glycan-binding proteins. Chem. Sci. 2022, 13 (25), 7644-7656.

4. Shuaishuai Wang;# Ding Liu;# Jingyao Qu; He Zhu; Congcong Chen; Christopher Gibbons; Harmon Greenway; Peng Wang; Roni J Bollag; Kebin Liu; Lei Li.* Streamlined subclass-specific absolute quantification of serum IgG glycopeptides using synthetic isotope-labeled standards. Anal. Chem. 2021, 93 (10), 4449-4455.

5. Shuaishuai Wang;# Congcong Chen;# Minhui Guan; Ding Liu; Xiu-Feng Wan; Lei Li.* terminal epitope-dependent branch preference of Siglecs toward N-glycans. Frontiers in Molecular Biosciences 2021, 8, 645999.

6. Shuaishuai Wang;# Congcong Chen;# Madhusudhan Reddy Gadi;# Varma Saikam;# Ding Liu; He Zhu; Roni Bollag; Kebin Liu; Xi Chen; Fengshan Wang; Peng G. Wang;* Peixue Ling;* Wanyi Guan;* Lei Li.* Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics. Nature communications 2021, 12 (1), 3573.

7. Shuang Li;# Shuaishuai Wang;# Yaqian Wang; Jingyao Qu; Xian-wei Liu; Peng George Wang; Junqiang Fang.* Gram-scale production of sugar nucleotides and their derivatives. Green Chem. 2021, 23 (7), 2628-2633.

8. He Zhu;# Shuaishuai Wang;# Ding Liu; Lang Ding; Congcong Chen; Yunpeng Liu; Zhigang Wu; Roni Bollag; Kebin Liu; William Max Alexander; Jun Yin; Cheng Ma; Lei Li;* Peng G. Wang.* Identifying sialylation linkages at the glycopeptide level by glycosyltransferase labeling assisted mass spectrometry (GLAMS). Anal. Chem. 2020, 92 (9), 6297-6303.

9. Shuaishuai Wang;# Qing Zhang;# CongCong Chen; Yuxi Guo; Madhusudhan Reddy Gadi; Jin Yu; Ulrika Westerlind; Yunpeng Liu; Xuefeng Cao; Peng G Wang;* Lei Li.* Facile chemoenzymatic synthesis of O‐mannosyl glycans. Angew. Chem. Int. Ed. 2018, 130 (51), 9412-9417.

10. Shuaishuai Wang; Xuan Fu; Yunpeng Liu; Xianwei Liu; Lin Wang; Junqiang Fang;* Peng G. Wang.* Probing the roles of conserved residues in uridyltransferase domain of Escherichia coli K12 GlmU by site-directed mutagenesis. Carbohydrate research 2015, 413, 70-74.

全部论文见Google Scholar Profile

学术论著章节

1. Shuaishuai Wang; Garrett A Edmunds; Lei Li; Congcong Chen; Peng G Wang. Introduction: Glycome and the Glyco-toolbox. In synthetic glycomes, Vol. 1; Royal Society of Chemistry, 2019; pp 1-14.

2. Lei Li; Wanyi Guan; Zhigang Wu; Shuaishuai Wang. Current Stage of Commercial Glycan Microarrays. In Synthetic Glycomes, Vol. 11; Royal Society of Chemistry, 2019; p 447.

课题组在生物化学与分子生物学、生物医药专业均招收硕士、博士研究生。欢迎有兴趣的考生报考！