刘长城 博士 副教授 博士生导师
山东大学，国家糖工程技术研究中心
山东省青岛市滨海路72号，淦昌苑F座228室，266237
电话：+86-532-5863-1415
传真：+86-532-5863-1405
Email: ccliu@sdu.edu.cn
教育经历：
2016 理学博士，北京大学药学院，导师：叶新山 教授
2010 工学学士，山东大学药学院，制药工程系
工作经历：
2021.9-今 副教授，山东大学国家糖工程技术研究中心
2017.7-2021.8 助理研究员，山东大学国家糖工程技术研究中心
2016.7-2017.6 研究科学家，北京安必奇生物科技有限公司
研究方向：
生物活性寡糖的高效酶法合成策略的发展；
高效生物催化策略的开发；
基于生物活性寡糖的疫苗、药物以及免疫疗法的开发。
科研项目
1. 国家自然科学基金面上项目，22277066，糖表位相关自身免疫性疾病治疗新策略研究，2023/01-2026/12，主持
2. 国家自然科学基金青年科学基金项目，21807064，使用Lewis x系列寡糖改善嵌合抗原受体T细胞在实体瘤组织中的浸润和粘附的研究，2019/01-2021/12，主持
3. 国家重点研发计划，以增加水溶性为导向的合成生物学创制子课题3，2018YFA0902002，2019/07-2024/06，主持
4. 山东省自然科学基金博士基金项目，ZR201709190252，基于肿瘤相关糖抗原的T细胞表位的鉴定与确证，2018/03-2020/12，主持
5. 山东大学未来青年学者，2019.09-2024.08。
发表论文：（*为通讯作者）
1. Chang-Cheng Liu, Jinfeng Ye, and Hongzhi Cao.* Chemical Evolution of Enzyme-Catalyzed Glycosylation. Acc. Chem. Res. 2024, 57, 636-647.
2. Lin Yang, Shuaishuai Wang, Changsheng Chen, Chang-Cheng Liu, Xiaoqin Wang, Shuang Li, Yi Li, Peixue Ling, Zhongfu Wang, and Junqiang Fang.* Programmable Enzymatic Toolbox for the Assembly of Fucosylated Chondroitin Derivatives. ACS Catal. 2024, 14, 670-677.
3. Na Lu, Yun Li, Hui Xia, Kan Zhong, Chenning Jia, Jinfeng Ye, Xianwei Liu, Chang-Cheng Liu,* Hongzhi Cao.* A Redox-Controlled Substrate Engineering Strategy for Site-Specific Enzymatic Fucosylation. Angew. Chem. Int. Ed. 2022, e202211032.
4. Chang-Cheng Liu, Chang-Xin Huo, Canjia Zhai, Xiu-Jing Zheng, De-Cai Xiong, and Xin-Shan Ye.* Synthesis and Immunological Evaluation of Pentamannose-Based HIV-1 Vaccine Candidates. Bioconjugate Chem., 2022, 33, 807-820.
5. Wenyuan Fang, Kan Zhong, Jiansong Cheng, Xian-Wei Liu, Chang-Cheng Liu,* Zhongfu Wang, Hongzhi Cao.* Capture-Release Strategy Facilitates Rapid Enzymatic Assembly of Oligosaccharides. Chin. J. Chem., 2022, 40, 343-350.
6. Hui Xia, Jinfeng Ye, Hongzhi Cao, Xianwei Liu, Yan Zhang, and Chang-Cheng Liu.* Enzymatic modular assembly of hybrid Lewis antigens. Org. Biomol. Chem., 2021, 19, 8041-8048
7. Weiying Hong#, Chang-Cheng Liu#, Henan Zhang, Zhiyong Chen, Min Xiao*, and Li Xu.* Cancer Cell Preferential Penetration and pH-Responsive Drug Delivery of Oligorutin. Biomacromolecules, 2021, 22, 9, 3679-3691
8. Kan Zhong, Jinfeng Ye, Xinhao Zhu, Hongzhi Cao, and Chang-Cheng Liu.* Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sda antigens. Green Chem., 2020, 22, 8002-8011.
9. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu,* Lei Li, * Fengshan Wang,* Peixue Ling* and Hongzhi Cao.* Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives. Chem. Commun., 2020, 56, 7549-7552.
10. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao.* Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.
11. Tian Gao#, Jingyu Yan#, Chang-Cheng Liu, Angelina S. Palma, Zhimou Guo, Min Xiao, Xi Chen, Xinmiao Liang, Wengang Chai, and Hongzhi Cao.* Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope. J. Am. Chem. Soc. 2019, 141, 19351-19359.
12. Na Lu#, Jinfeng Ye#, Jiansong Cheng#, Aniruddha Sasmal#, Chang-Cheng Liu, Wenlong Yao, Jun Yan, Naazneen Khan, Wen Yi, Ajit Varki, Hongzhi Cao.* Redox-controlled site-specific α2-6-sialylation. J. Am. Chem. Soc. 2019, 141, 4547-4552.
13. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki, Fengshan Wang,* Hongzhi Cao.* Chemoenzymatic assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018, 57, 9003-9007.
14. Chengcheng Song, Xiujing Zheng, Chang-Cheng Liu, Yifa Zhou, Xinshan Ye.* A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model, Oncotarget, 2017, 8, 47330-47343.
15. Chang-Cheng Liu, Canjia Zhai, Xiujing Zheng, Xinshan Ye.* Altering the specificity of the antibody response to HIV gp120 with a glycoconjugate antigen, ACS Chemical Biology, 2016, 11, 1702-1709.
16. Chang-Cheng Liu, Xiujing Zheng, Xinshan Ye.* Broadly neutralizing antibody-guided carbohydrate-based HIV vaccine design: challenges and opportunities，ChemMedChem，2016, 11, 357-362.
17. Changxin Huo, Xiujing Zheng, An Xiao, Chang-Cheng Liu, Shuang Sun, Zhuo Lv, Xinshan Ye.* Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates, Organic ＆ Biomolecular Chemistry, 2015, 13, 3677-3690.
18. Chang-Cheng Liu, Xinshan Ye.* Carbohydrate-based cancer vaccines: target cancer with sugar bullets, Glycoconjugate Journal, 2012, 29, 259-271.
