吴选俊 教授 博士生导师

山东省优秀青年基金获得者

山东省泰山学者青年专家

山东大学齐鲁青年学者

通讯地址：山东省青岛市即墨滨海公路72号山东大学青岛校区K6-206室

办公室电话：(0532)-58631426

邮箱：xuanjun@sdu.edu.cn

教育经历

2010.9-2015.6   厦门大学 化学生物学系，理学博士，导师: 韩守法教授

2005.9-2009.7   安徽农业大学 生物技术专业，理学学士

工作经历

2019.6-今          山东大学国家糖工程技术研究中心，齐鲁青年学者/教授

2015.7-2019.5   美国密歇根州立大学化学系，博士后，导师: 黄雪飞教授

研究方向

新型糖疫苗及相关抗体药物研发

奖励与荣誉

全国糖生物学会议暨第六届全国糖化学会议-青年优秀报告奖二等奖（2025年）

山东省泰山学者青年专家（2023年）

福建省科学技术进步奖二等奖（2019年）

厦门市科学技术进步奖二等奖（2019年）

福建医学科技奖二等奖（2018年）

博士研究生国家奖学金（2014年）

教育部博士学术新人奖（2012年）

科研项目

1.国家自然科学基金面上项目，2024-01至2027-12，在研，主持

2.山东省泰山学者项目，2024-01至2026-12，在研，主持

3.山东省优秀青年基金，2023-01至2025-12，在研，主持

4.国家自然科学基金青年科学基金，2021-01至2023-12，结题，主持

5.山东省自然科学基金青年基金，2021-01至2023-12，结题，主持

6.江苏省自然科学基金青年基金，2020-07至2023-06，结题，主持

7.山东大学微生物技术国家重点实验室开放课题基金，2020-07至2021-07，结题，主持

8.山东大学齐鲁青年学者基金，2019-05至2024-05，结题，主持

代表性论文（*，通讯作者）

1. Li, E.; Yang, C.; Wang, Q.; Dong, H.; Cheng, Z.; Wang, W.; Wu, X.*; Chiu, S.* A Self-Assembled RSV-DS2 Based Nanovaccine Elicits a Strong Immune Response Against Respiratory Syncytial Virus Infection. Adv. Funct. Mater. 2026, 36, e10925.

2. Yang, C; Wang, Y.; Han, Y.; Dong, H.; Tong, W.; Wu, X.* Novel Nanoadjuvant for Subunit Vaccines: Cyclic Seven-Membered Tertiary Amine-Based Polymer-Grafted Ethoxy-Acetalated Dextran Nanoparticles Encapsulating CpG Oligodeoxynucleotides. Mol. Pharmaceutics 2025, 22 (10), 5831–5844.

3. Wang, Y.; Zhao, Q.; Wu, X.* Development of Globo-H conjugated bacteriophage Qβ mutant virus-like particles as an anticancer vaccine. Chin. Chem. Lett. 2025, DOI: 10.1016/j.cclet.2025.111642.

4. Zhang, S.; Dong, Hi.; Wen, S.; Lin, Z.; Wu, X.*; Han, J.*; Han, S.* A Sialic Acid-Caged Generic Platform for Sialoengineering of Tumors with Artificial Immuno-Ligand. Health and Metabolism 2025, DOI: 10.53941/hm.2025.100023.

5. Yang, C.; Li, E.; Guo, X.; Xie, W.; Wang, Y.; Huang, X.; Chiu, S.*; Wu, X.* A Self-Assembled Nanovaccine with BA.4/5 Receptor-Binding Domain and CpG Oligodeoxynucleotides Induces Broad-Spectrum Neutralization against SARS-CoV-2 Omicron Subvariants. ACS Nano 2025, 19 (17), 16424–16437.

6. Zhao, Q.; Huang, X.; Wu, X.* Development of NHAcGD2/NHAcGD3 conjugates of bacteriophage MX1 virus-like particles as anticancer vaccines. RSC Adv. 2024, 14 (9), 6246–6252.

7. Dong, H.; Huang, X.; Wu, X.* Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy. Biomater. Sci. 2023, 11 (18), 6160–6166.

8. Wang, J.; Yang, C.; Gao, Y.; Wu, X.* Development of superior nanotheranostic agents with indocyanine green-conjugated poly(styrene-alt-maleic acid) nanoparticles for tumor imaging and phototherapy. J. Mater. Chem. B. 2023, 11 (28), 6560–6566.

9. Gao, Y.; Wang, W.; Yang, Y.; Zhao, Q.; Yang, C.; Jia, X.; Liu, Y.; Zhou, M.; Zeng, W.; Huang, X.; Chiu, S.; Jin, T.; Wu, X.* Developing Next-Generation Protein-Based Vaccines Using High-Affinity Glycan Ligand-Decorated Glyconanoparticles. Adv. Sci. 2023, 10 (2), 2204598.

10. Dong, H.; Gao, Y.; Huang, X.; Wu, X.* Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy. J. Mater. Chem. B. 2022, 10 (6), 927–934.

11. Sungsuwan, S.; Wu, X.; Shaw, V.; Kavunja, H.; McFall-Boegeman, H.; Rashidijahanabad, Z.; Tan, Z.; Lang, S.; Nick, S. T.; Lin, P.-h.; Yin, Z.; Ramadan, S.; Jin, X.*; Huang, X.* Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines. ACS Chem. Biol. 2022, 17 (11), 3047–3058.

12. Wu, X.; Ye, J.; DeLaitsch, A. T.; Rashidijahanabad, Z.; Lang, S.; Kakeshpour, T.; Zhao, Y.; Ramadan, S.; Saavedra, P. V.; Yuzbasiyan-Gurkan, V.; Kavunja, H.; Cao, H.*; Gildersleeve, J. C.*; Huang, X.* Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome the Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development. Angew. Chem., Int. Ed. 2021, 60 (45), 24179–24188.

13. Gao, Y.; Zhao, Q.; Dong, H.; Xiao, M.; Huang, X.; Wu, X.* Developing Acid-Responsive Glyco-Nanoplatform Based Vaccines for Enhanced Cytotoxic T-lymphocyte Responses Against Cancer and SARS-CoV-2. Adv. Funct. Mater. 2021, 31 (41), 2105059.

14. Gao, Y.; Zhao, Q.; Xiao, M.; Huang, X.; Wu, X.* A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy of cancer. Biomaterials 2021, 273, 120792.

15. Zhao, Q.; Gao, Y.; Xiao, M.; Huang, X.; Wu, X.* Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates. Chem. Commun. 2021, 57 (12), 1474–1477.

16. Wu, X.; McFall-Boegeman, H.; Rashidijahanabad, Z.; Liu, K.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Behren, S.; Westerlind, U.; Huang, X.* Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen-Friedenreich conjugate. Org. Biomol. Chem. 2021, 19 (11), 2448–2455.

17. Wu, X.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Lang, S.; Behren, S.; Westerlind, U.; Finn, M. G.; Huang, X.* Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles. ACS Chem. Biol. 2019, 14 (10), 2176–2184.

18. Wu, X.; Yin, Z.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Gohl, T.; Sungsuwan, S.; Ramadan, S.; Baniel, C.; Allmon, A.; Das, R.; Westerlind, U.; Finn, M. G.; Huang, X.* Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice. J. Am. Chem. Soc. 2018, 140 (48), 16596–16609.

19. Yin, Z.; Wu, X.; Kaczanowska, K.; Sungsuwan, S.; Aragones, M. C.; Pett, C.; Yu, J.; Baniel, C.; Westerlind, U.; Finn, M. G.; Huang, X.* Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Qβ in Wild-type Mice. ACS Chem. Biol. 2018, 13 (6), 1668–1676.

20. Lin, B.; Wu, X.; Zhao, H.; Tian, Y.; Han, J.; Liu, J.; Han, S.* Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface. Chem. Sci. 2016, 7 (6), 3737–3741.

21. Wu, X.; Lin, B.; Yu, M.; Yang, L.; Han, J.; Han, S.* A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging. Chem. Sci. 2015, 6 (3), 2002–2009.

22. Wu, X.; Yu, M.; Lin, B.; Xing, H.; Han, J.; Han, S.* A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation. Chem. Sci. 2015, 6 (1), 798–803.

23. Wu, X.; Tian, Y.; Yu, M.; Han, J.; Han, S.* A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors. Biomater. Sci. 2014, 2 (7), 972–979.

24. Wu, X.; Tian, Y.; Yu, M.; Lin, B.; Han, J.; Han, S.* A fluorescently labelled sialic acid for high performance intraoperative tumor detection. Biomater. Sci. 2014, 2 (8), 1120–1127.

25. Wu, X.; Shi, J.; Yang, L.; Han, J.; Han, S.* A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum. Bioorg. Med. Chem. Lett. 2014, 24 (1), 314–316.

26. Wu, X.; Li, Z.; Yang, L.; Han, J.; Han, S.* A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells. Chem. Sci. 2013, 4 (1), 460–467.

27. Wu, X.; Song, Y.; Han, J.; Yang, L.; Han, S.* Traceless protein delivery with an efficient recyclable nanocarrier. Biomater. Sci. 2013, 1 (9), 918–923.

28. Wu, Z.; Wu, X.; Li, Z.; Yang, Y.; Han, J.; Han, S.* Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid. Bioorg. Med. Chem. Lett. 2013, 23 (15), 4354–4357.

29. Wu, X.; Wu, S.; Yang, L.; Han, J.; Han, S.* Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics. J. Mater. Chem. 2012, 22 (33), 17121–17127.

30. Wu, X.; Wu, Z.; Yang, Y.; Han, S.* A highly sensitive fluorogenic chemodosimeter for rapid visual detection of phosgene. Chem. Commun. 2012, 48 (13), 1895–1897.

31. Wu, X.; Wu, Z.; Han, S.* Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor. Chem. Commun. 2011, 47 (41), 11468–11470.

授权国家发明专利

1. ZL 2023 1 0780016.8，一种唾液酸-喜树碱前药Sia-ss-CPT及其制备方法与应用，发明人：吴选俊，董会玲

2. ZL 2022 1 1340059.6，一种基于高亲和力Siglec-1配体修饰的葡聚糖纳米疫苗及其制备方法和应用，发明人：吴选俊，高亚楠

3. ZL 2021 1 1644096.1，一种唾液酸连接吲哚菁绿Sia-ICG及其制备方法和应用，发明人：吴选俊，董会玲

指导研究生获奖情况

指导博士生获第二届“惠永正糖科学奖·优秀学业奖”、山东大学校长奖、博士研究生国家奖学金等奖项；指导多名硕士生获硕士研究生国家奖学金。

本课题组在生物化学与分子生物学和生物医药专业均招收硕士、博士研究生。欢迎有兴趣的考生报考！