Xinying Ma, Meifeng Chen, Xia Li, Anurag Purushothaman, and Fuchuan Li *

Int. J. Electrochem. Sci., 2012, 7: 991 - 1000

ABSTRACT

A glassy carbon electrode was modified with graphene. In phosphate buffer solution, the modified electrode showed an excellent electrocatalytical effect on the oxidation of norepinephrine (NE). This was further used to determine NE in the presence of epinephrine, uric acid and ascorbic acid by cyclic voltammetry. The reduction peak current showed a linear relationship with the concentrations of NE in the range of 6.00×10-7 to 1.20×10-4 mol·L-1, with the detection limit of 4.00×10-7 mol·L-1. The modified electrode can be used to selectively determine NE in the presence of epinephrine, uric acid and ascorbic acid by measuring reduction peak current in PBS pH 7.0. The method has high sensitivity, selectivity, stability, and has been successfully applied to analyzing injection samples of NE.