Jian Gao, Guochao Liao, Lizhen Wang, and Zhongwu Guo^*

Org. Lett. 2014, 16, 988−991

ABSTRACT

An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.