|
Name: YikangShi |
Tel: 15953100829 |
Associate professor |
Supervisor: |
E-mail: shiyikang@sdu.edu.cn |
Address: room208, Building F, Qingdao campus, Shandong University |
Education
Degree |
Date |
Affiliation |
Major |
PhD |
2002.09-2005.07 |
Peking Union Medical College |
Microbiology and Biochemical Pharmacy |
Master |
1994.09-1997.07 |
Shandong Academy of Medical Sciences |
Hygienic Toxicology |
Bachelor |
1988.09-1993.07 |
West China University of Medical Sciences |
Sanitary Inspection and Quarantine |
Research Experience
Date |
Affiliation |
Position |
2011.09-2012.09 |
Johns Hopkins University |
Visiting scholar |
2006.03-2007.12 |
University of Pittsburgh |
Postdoctor |
2000.09-2001.09 |
University of Toronto |
Visiting scholar |
Research Interests
Chemotherapy has been widely used for cancer treatment, however, most anticancer drugs have serious toxicity and poor water solubility. Owning to its high biocompatibility, excellent water solubility, and biodegradability, polysaccharide dextran has been used as nanocarrier for drug delivery. My research focus on developing nanoparticles through coupling dextran with anticancer drugs such as paclitaxel, docetaxel and cabazitaxel. Dextran-based conjugates exhibit superior antitumor efficacy with decreased systemic side effects. Some of these conjugates are under preclinical investigation.Another interest is to study the biological functions of protein O-GlcNAcylation in cancer initiation, progression and treatment.
Representative Publications
1. Wang D, Wu J, Wang D, Huang X, Zhang N, Shi Y. Cisplatin enhances protein O‑GlcNAcylation by altering the activity of OGT, OGA and AMPK in human non‑small cell lung cancer cells. Int J Oncol. 2021 Jun;58(6):27.
2. Zhang Y, Khan AR, Yang X, Shi Y, Zhao X, Zhai G. A sonosensitiser-based polymeric nanoplatform for chemo-sonodynamic combination therapy of lung cancer. J Nanobiotechnology. 2021 Feb 25;19(1):57.
3. Zheng X, Zhu L, Li T, Xu W, Liu D, Sheng J, Cao H, Shi Y, Wang F. Improve Stability of Bioactive Peptides by Enzymatic Modular Synthesis of Peptides with O-Linked Sialyl Lewis x. ACS Catal. 2021, 11, 13, 8042–8048
Patents
1. Title: The synthetic method and application of a dextran-based conjugate coupled with DHA. Patient No.: ZL 2020103213560
2. Title: Paclitaxel-lipid-polysaccharidedual-type conjugate preparation method therefor and use thereof. Patient No.: PCT/CN2019/092101
