|
Name: Wang Qian |
Tel: 0532-58631580 |
Title: Prof. |
Supervisor: Doctoral advisor |
E-mail: qiqi20011983@gmail.com |
Address: N1-236, Shandong university, 72 Binhai Road, Jimo, Qingdao |
Education
Degree |
Date |
Affiliation |
Major |
PhD |
2004-2009 |
Shandong Unviversity |
Microbiology |
Bachelor |
2000-2004 |
Shandong Agricultural University |
Biotechnology |
Research Experience
Date |
Affiliation |
Position |
2010-2020 |
National Glycoengineering Research Center |
Associate professor |
2020- |
National Glycoengineering Research Center |
Professor |
Research Interests
Synthetic biology, metabolic engineering
1. Bacterial metabolism regulation
2. Using microbial cell factory to synthesize bio-based compounds amino acids and sugars.
3. Development and utilization of synthetic biology tools
4. Construction and application of metabolite biosensors
Representative Publications
1. Jian Zhang, Zhiguo Wang, Tianyuan Su, Huanhuan Sun, Yuan Zhu, Qingsheng Qi*, QianWang*. Tuning the Binding Affinity of Heme-Responsive Biosensor for Precise and Dynamic Pathway Regulation. iScience. 23, 5, 22 May 2020, 101067.
2. In vivo evolutionary engineering of riboswitch with high-threshold for N-acetylneuraminic acid production.Metabolic Engineering, Metab Eng. 2020 May; 59:36-43.
3. Qingxiao Pang, Hao Han, Ya Xu, Xiaoqin Liu, Qingsheng Qi*, Qian Wang*. Exploring Amino Sugar and Phosphoenolpyruvate Metabolism to ImproveEscherichia coli N-Acetylneuraminic Acid Production.J Agric Food Chem. 2020 Oct 21; 68(42):11758-11764.
4. Ying Li, Zhijie Sun, Ya Xu, Yaqi Luan, Jiasheng Xu, Quanfeng Liang, Qingsheng Qi, Qian Wang*. Enhancing the Glucose Flux of an Engineered EP-Bifido Pathway for High Poly(Hydroxybutyrate) Yield Production.Front Bioeng Biotechnol. 2020 Aug 27; 8:517336.
5. Xiaoli Yu, Changsen Lin, Jing Yu, Qingsheng Qi*, Qian Wang*. BioengineeredEscherichia coli Nissle 1917 for tumour-targeting therapy.Microb Biotechnol. 2020 May; 13(3):629-636.
6. Ding Zhou, Zhennan Jiang, Qingxiao Pang, Yuan Zhu,Qian Wang*, Qingsheng Qi, CRISPR/Cas9-Assisted Seamless Genome Editing inLactobacillus plantarum and Its Application in N-Acetylglucosamine Production.Appl. Environ. Microbiol.2019 Aug 23. pii: AEM.01367-19.
7. Tianyuan Su, Qi Guo, Yi Zheng, Quanfeng Liang,Qian Wang* and Qingsheng Qi* Fine-tuning ofhemB using CRISPRi for increasing 5-aminolevulinic acid production inEscherichia coli.Frontiers in Microbiology. 2019 Jul 31; 10:1731.
8. Zhiyong Cui, Zhennan Jiang, Jinhong Zhang, Huihui Zheng, Xin Jiang, Kai Gong, Quanfeng Liang,Qian Wang*, Qingsheng Qi,Stable and Efficient Biosynthesis of 5-Aminolevulinic Acid Using Plasmid-FreeEscherichia coli. J Agric Food Chem.2019, 67, 5, 1478-1483.
9. Qian Wang;Jiasheng Xu ; Zhijie Sun; Yaqi Luan; Ying Li; Junshu Wang; Quanfeng Liang; Qingsheng Qi , Engineering an in vivo EP-bifido pathway in Escherichia coli for high-yield acetyl-CoA generation with low CO2 emission.,Metabolic Engineering, 2018.8.10, 51: 79~87.
10. Peng Yang; Jing Wang; Qingxiao Pang; Fengyu Zhang; Junshu Wang;Qian Wang*; Qingsheng Qi*, Pathway optimization and key enzyme evolution of N-acetylneuraminate biosynthesis using an in vivo aptazyme-based biosensor,Metabolic Engineering, 2017.09, 43: 21~28.
Honors and Awards
Future Plan for Young Scholars of Shandong University
Patents
Wang Qian; Liu Wenjing; Qi Qingsheng, A method for anaerobic production of 5-aminolevulinic acid using recombinant E. coli, 2017.4.26, China, ZL201410448698.3.
