Education

Research Experience

Research Interests

1. Development of ganglioside based anticancer vaccines

2. Development of MUC1 based anticancer vaccines

3. Cytotoxic T cell immunotherapy of cancer

4. Development of vaccines against viruses

Representative Publications

1. X Wu, J Ye, A T. DeLaitsch, Z Rashidijahanabad, S Lang, T Kakeshpour, Y Zhao, S R, P V Saavedra, V Yuzbasiyan-Gurkan, H Cao,* J Gildersleeve,* and X Huang*. Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development,Angew. Chem. Int. Ed. 2021, DOI: 10.1002/anie.202108610.(IF=15.336)

2. X Wu, Z Yin, C McKay, C Pett, J Yu, M Schorlemer, T Gohl, S Sungsuwan, S Ramadan, C Baniel, Anthony, R Das, U Westerlind, M. Finn, and X Huang*. Protective epitope discovery and the design of MUC1 based vaccine for effective tumor protections in immunotolerant mice.J. Am. Chem. Soc., 2018,140, 16596–16609. (IF =15.419)

3. Y Gao, Q Zhao,H Dong, M Xiao, X Huang,X Wu*, Developing acid-responsive glyco-nanoplatform based vaccines for enhanced cytotoxic T-lymphocyte responses against cancer and SARS-CoV-2, Adv. Funct. Mater.,2021, DOI:10.1002/adfm.202105059. (IF=18.808)

4. Y Gao, Q Zhao, M Xiao, X Huang,X Wu*, A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy ofcancer, Biomaterials,2021,273, 120792. (IF=12.479)

5. Q Zhao, Y Gao, M Xiao, X Huang,X Wu*, Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates,Chem. Commun., 2021,57, 1474–1477.(IF =6.222)

6. X Wu, H McFall-Boegeman, Z Rashidijahanabad, K Liu, C Pett, J Yu, M Schorlemer, S Ramadan, S Behren, U Westerlind and X Huang, Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate, Org. Biomol. Chem., 2021,19, 2448–2455. (IF =3.876)

7. X Wu, C McKay, C Pett, J Yu, M Schorlemer, S Ramadan, S Lang, U Westerlind, M. Finn, and X Huang*. Synthesis and immunological evaluation of disaccharide bearing MUC-1 glycopeptide conjugates with virus-like particles. ACS Chem. Biol. 2019,14, 2176–2184. (IF =5.100)

8. Z Yin†,X Wu†, K Kaczanowska, S Sungsuwan, Aragones, C Pett, J Yu, C Baniel, U Westerlind, M Finn, and X Huang*. Anti-tumor humoral and T cell responses by mucin-1 conjugates of bacteriophage Qb in wildtype mice.ACS Chem. Biol. 2018,13, 1668–1676. (†, contributed equally) (IF =5.100)

9. B Lin†,X Wu†, H Zhao, Y Tian, J Han, J Liu, S Han*. Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface.Chem. Sci., 2016,7, 3737–3741. (†, contributed equally) (IF =9.825)

10. X Wu, B Lin, M Yu, L Yang, J Han, S Han*. A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging.Chem. Sci. 2015,6, 2002–2009. (IF =9.825)

11. X Wu, M Yu, B Lin, H Xing, J Han, S Han*. A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation.Chem. Sci. 2015.6, 789–803. (IF =9.825)

12. X Wu, Y Tian, M Yu, J Han, S Han*. A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors.Biomater. Sci. 2014,2, 972–979. (IF =6.843)

13. X Wu, Y Tian, M Yu, B Lin, J Han, S Han*. A fluorescently labelled sialic acid for high performance intraoperative tumor detection.Biomater. Sci. 2014,2, 1120–1127. (IF =6.843)

14. X Wu, J Shi, L Yang, J Han, S Han*. A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum.Bioorg Med Chem Lett. 2014,24, 314–316. (IF =2.448)

15. X Wu, Z Li, L Yang, J Han, S Han*. A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells.Chem. Sci. 2013,4, 460–467. (IF =9.825)

16. X Wu, Y Song, J Han, L Yang, S Han*. Traceless protein delivery with an efficient recyclable nanocarrier.Biomater. Sci. 2013,1, 918–923. (IF =6.843)

17. Z Wu†,X Wu†, Z Li, Y Yang, J Han, S Han*. Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid.Bioorg Med Chem Lett 2013,23, 4354–4357. (†, contributed equally) (IF =2.448)

18. X Wu, S Wu, L Yang, J Han, S Han*. Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics.J. Mater. Chem. 2012,22, 17121–17127. (IF =6.626)

19. X Wu, Z Wu, Y Yang, S Han*. A highly sensitive fluorogenicchemodosimeter for rapid visual detection of phosgene.Chem. Commun. 2012,48, 1895–1897. (IF =6.222)

20. X Wu, Z Wu, S Han*. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor.Chem. Commun. 2011,47, 11468–11470. (IF =6.222)

Honors and Awards

1. 2012, the Ministry of Education's Doctoral Newcomer Award, Ministry of Education, China

2. 2014, National Scholarship for Doctoral Candidates, Ministry of Education, China

3. 2018, Medical Science and Technology Award of Fujian Province, Fujian, China

4. 2019, Science and Technology Progress Award of Xiamen, Xiamen, China

5. 2019, Science and Technology Progress Award of Fujian Province, Fujian, China