|
Name: Guofeng Gu |
Tel:0532-58631408 |
Title: Professor |
Supervisor: Doctoral advisor |
E-mail: guofenggu@sdu.edu.cn |
Address: Room 123, Ganchang Building-F |
Education
Degree |
Date |
Affiliation |
Major |
PhD |
2004.7 |
Research Center for Eco-Environmental Sciences, CAS |
Organic Chemistry |
Bachelor |
1999.7 |
ShandongNormal University |
Chemistry Education |
Research Experience
Date |
Affiliation |
Position |
2008- |
Shandong University |
Associate Professor/Professor |
2004.8-2017.12 |
Simon Fraser University |
Postdoc |
1999.9-2004.7 |
Research Center for Eco-Environmental Science, CAS |
PhD student |
Research Interests
1.Synthesis and biological evaluation of natural glycosylated products;
2. The development of oligosaccharide-based glycoproteins/glycolipid vaccines against bacterial infectious diseases;
3. The development of novel carrier molecules for glycoconjugate vaccines.
Representative Publications
1. Xueyun Geng, Guirong Wang, Zhongwu Guo, and Guofeng Gu*. Synthesis of the oligosaccharides of Burkholderia pseudomallei and B. malleicapsular polysaccharide and preliminary immunological studies of their protein conjugates. J. Org. Chem. 2020, 85, 2369–2384.
2. Subo Wang, Yisheng Zhao, Guirong Wang, Shaojie Feng, Zhongwu Guo, and Guofeng Gu*. Group A Streptococcus cell wall oligosaccharide-streptococcal C5a peptidase conjugates as effective antibacterial vaccines. ACS Infect. Dis. 2020, 6, 281–280.
3. Yisheng Zhao, Subo Wang, Guirong Wang, Hui Li, Zhongwu Guo, and Guofeng Gu*. Synthesis and immunological studies of group A Streptococcus cell-wall oligosaccharide–streptococcal C5a peptidase conjugates as bivalent vaccines. Org. Chem. Front. 2019, 6,3589–3596.
4. Shaojie Feng, Chenghe Xiong, Subo Wang, Zhongwu Guo*, and Guofeng Gu*. Semisynthetic glycoconjugate vaccines to elicit T cell-mediated immune responses and protection against Streptococcus pneumonia serotype 3. ACS Infect. Dis. 2019, 5, 1423–1432.
5. Chenghe Xiong, Shaojie Feng, Yin Qiao, Zhongwu Guo*, and Guofeng Gu*. Synthesis and immunological studies of oligosaccharides that consist of the repeating unit of Streptococcus pneumonia serotype 3 capsular polysaccharide (hot paper). Chem. Eur. J. 2018, 24, 8205–8216.
6. Kang Yu, Ningning Bi, Chenghe Xiong, Shuihong Cai, Zhongzhu Long, Zhongwu Guo*, and Guofeng Gu*. Synthesis of defined and functionalized glycans of lipoteichoic acid: A cell surface polysaccharide from Clostridium difficile. Org. Lett. 2017, 19, 3123−3126.
